Calcium Channel Blockers

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Calcium channel blockers, such as verapamil, work by preventing the narrowing (constriction) of blood vessels that occurs during the initial phases of migraine attacks. Although proved effective in decreasing the frequency of migraine attacks, they do not affect the migraine headache intensity and duration.

• These drugs are sometimes prescribed for headache prevention, even though data are insufficient to support this use.
• Potential side effects include depression, tremors, and weight gain.
• Patients suffering from low blood pressure should not use calcium channel blockers.