Ergotamine Compounds

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Ergotamine compounds are used to treat moderate migraine pain after analgesics and nonsteroidal inflammatory drugs (NSAIDs) have proved ineffective.

• The absorption of these drugs is increased by caffeine.
• Nasal inhalation of dihydroergotamine is fairly well tolerated and poses less risk of headache recurrence than sumatriptan.
• These drugs are habit forming, and their side effects may include nausea, vomiting, diarrhea, muscle cramps, chest pain, and tingling sensations.
• Ergotamine compounds should not be used during pregnancy or by patients who have high blood pressure; elevated risk for heart attack as determined by such risk factors as family history of heart disease, elevated cholesterol, obesity, and cigarette smoking; and other circulatory problems.