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Learn More: Headache Center

Medication-Overuse Headaches

Medications that are prescribed for treating conditions other than headaches sometimes cause headaches as a side effect.

  • One example is nitroglycerin, which is prescribed for people with heart disease. This medication enlarges (dilates) blood vessels, an event that can trigger a headache.
  • Other medications known to cause headaches in some individuals include birth control pills, nifedipine, indomethacin, cimetidine, resperine, and theophylline.

If you are taking any medications -- prescription medications, nonprescription medications, or herbal products -- and suspect that they are causing your headaches, note the following information during your next five to seven headache attacks:

  • time that you take the medication
  • time that you experience the headache

Headache Diary

After tracking this information, if you notice a correlation between your medication and headaches, consult your physician.

Fluctuating daily headaches may occur as a result of chronic use of certain headache medications, caffeine, or both.

  • Ergotamine medications that are prescribed to relieve the pain of migraine headaches may produce rebound headaches, sometimes referred to as ergotamine-abuse headaches.
  • Daily, or near-daily, overuse of common nonprescription medications, such as aspirin or acetaminophen, may lead to analgesic-abuse headaches.

Treating medication-overuse headaches requires that use of the medication causing the headaches be stopped completely; moreover, the medication must be avoided for 8 to 12 weeks.

  • Some patients successfully discontinue medications on an outpatient basis.
  • While some of these individuals are able to stop using headache medications abruptly, others need to lower the dose gradually over several weeks.
  • Other patients require hospitalization during the withdrawal process.
  • Over several weeks, medication-overuse headaches shift from a chronic and daily occurrence to a sporadic event. Ultimately, the frequency of headaches returns to the level that existed before medication abuse.
Last reviewed on: May 2010
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