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Learn More: Headache Center

Monoamine Oxidase Inhibitors

Monoamine oxidase inhibitors (MAOIs), such as phenelzine sulfate, are last-resort drugs used as a preventive treatment for headaches that are unresponsive to other treatments. MAOIs act by preventing the narrowing (constriction) and expansion (dilation) of blood vessels.

  • Possible side effects include dizziness, insomnia, constipation, skin rashes, and low blood pressure.
  • These drugs have problematic interactions with foods that contain the substance tyramine; thus, people using MAOIs must follow a special diet, avoiding foods such as aged cheese, beer, and wine.
  • MAOIs should be used with caution by patients who have kidney disease, seizure disorders, cardiovascular disease, or a condition in which an excess of a particular hormone (parathyroid hormone) disturbs several intricately balanced chemical systems in the body (hyperparathyroidism). Pregnant or nursing women should not use MAOIs.

Last reviewed on: May 2010
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