Learn More: Headache Center
Monoamine Oxidase Inhibitors
Monoamine oxidase inhibitors (MAOIs), such as phenelzine sulfate, are last-resort drugs used as a preventive treatment for headaches that are unresponsive to other treatments. MAOIs act by preventing the narrowing (constriction) and expansion (dilation) of blood vessels.
- Possible side effects include dizziness, insomnia, constipation, skin rashes, and low blood pressure.
- These drugs have problematic interactions with foods that contain the substance tyramine; thus, people using MAOIs must follow a special diet, avoiding foods such as aged cheese, beer, and wine.
- MAOIs should be used with caution by patients who have kidney disease, seizure disorders, cardiovascular disease, or a condition in which an excess of a particular hormone (parathyroid hormone) disturbs several intricately balanced chemical systems in the body (hyperparathyroidism). Pregnant or nursing women should not use MAOIs.










