Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

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Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and naproxen, are anti-inflammatory drugs that relieve pain by inhibiting prostaglandins, compounds implicated in the inflammatory responses. These drugs help reduce the swelling associated with the pain of headaches.

• NSAIDs, along with analgesics, are considered a first-line treatment for sufferers of mild to moderate headache pain.
• These medications have been proved effective in preventing migraines; in particular, naproxen is especially effective in preventing menstrual migraines.
• NSAIDs may be taken in conjunction with metoclopramide as first-line treatment for migraines to reduce nausea and/or vomiting.
• The most common side effects of these drugs include stomach irritation, allergic reaction, nausea, vomiting, abdominal pain, diarrhea, lightheadedness, drowsiness, fluid retention, and liver and kidney toxicity.
• Individuals who are suffering from stomach ulcers should not take NSAIDs.