Tricyclic Antidepressants

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Tricyclic antidepressants, such as amitriptyline, are used successfully by some individuals for preventive treatment of migraine attacks.

• These medications are proved to reduce headache severity, frequency, and duration; they are often prescribed for chronic tension-type headaches.
• Possible side effects include increased appetite and weight gain.
• Patients who have abnormal heart rhythms should not use tricyclic antidepressants.